BIOPRECURSOR PRODRUGS PDF

THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.

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Disulfide reduction thiamin tetrahydrofurfuryl disulfide thiamin 3. Enter the prodruga by crossing barriers Distributed by the blood to the site of action Biotransform.

My presentations Profile Feedback Log out. Prodrugs to minimize toxicity aspirin anti-inflammatory ester derivative of aspirin a. Cancer Chemotherapy Tumor cells have a much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to prkdrugs sites and exploit higher enzyme activity Example: You are a scientist wanting to formulate this drug for parenteral administration.

Examples of Carrier-linked Bipartate Prodrugs 3. However, activated amides or amides of amino acids are more susceptible to enzyme mediated cleavage.

Sites of Administration Sites of action Cell membrane. Examples of Carrier-linked Bipartate Prodrugs 6. In order to view it, please contact the author of the presentation.

Disposition of Chemical Compounds. To make this website work, we log user data and share it with processors. The lecturer also mentioned that the drugs could sometimes be serendipitously be discovered in their pprodrugs form from a natural source, which makes it cheaper to produce them by harvesting from the source and be used just like that. Download ppt “Bioprecursor Prodrugs”. Google doesn’t tell me the answer, oddly enough. WordPress Embed Customize Embed.

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To use this website, you must agree to our Privacy Policyincluding cookie policy. Azo reduction prontosil sulfanilamide b. This may be helpful for increasing bioavailability, or also if the drug itself is nonspecific in its action. Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient. Auth with social network: Oxidative Activation 5, 6 dihydropyridine bioprecursor d.

Examples of Carrier-linked Bipartate Prodrugs 4. Download ppt “Bioprecursor Prodrugs”. What types of groups are the easiest to cleave from a carrier? Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production.

Phosphorylation Activation ganciclovir substrate for DNA polymerase 5. What the body does to the drug?

Bioprecursor Prodrugs – ppt video online download

Published by Aubrey Johnston Modified over 3 years ago. Automatically changes to Flash or non-Flash embed. Registration Forgot your password? You do not have the permission to view this presentation. Enzymes — not just your run of the mill protein! To make this website work, we log user data and share it with processors.

Disposition of Chemical Compounds. Epinephrine boprecursor dipivefrin esterase. About project SlidePlayer Terms of Service. N-Oxidation pralidoxime acetylcholine esterase activator e.

Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Prodruga Why have such prodrugs if they are biopdecursor utilised for the purpose of increasing the rate of transportation across the cell membrane?

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By using our site, you consent to the use of cookies by us. Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents. Prodrugs to encourage patient acceptance clindamycin antibacterial. Auth with social network: Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Enzymes — not just your run of the mill protein!

To use this website, you must agree to our Privacy Policyincluding cookie policy. Anti-inflammatory drug Tolmetin has a peak plasma concentration of about 1 hr. Examples of Carrier-linked Biopercursor Prodrugs 5.

Home Biiprecursor Search Login Register. BillJames on May 10, Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient. About project SlidePlayer Terms of Service.