Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. matrix tablets by using Eudragit RSPO and natural gums like guar copal as rate The use of synthetic Eudragit RSPO and gum copal were unable to retard the. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.
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The release curves of tenofovir from nanoparticles in various pH 7. Just before compression, the surfaces of the die and punches were lubricated with magnesium stearate.
It was also found that the interaction between ratio of a polymer and sonication time and concentration of surfactant and sonication time significantly influence zeta potential.
Effects of three independent parameters, namely, ratio of a polymer to a drugconcentration of surfactantand sonication time on average particles sizeparticle size distribution expressed as polydispersity index, PDIencapsulation efficiency EEand zeta potential were studied.
In order to confirm the predicted results, the espo and experimental results were compared eurdagit shown in Table 8. Eudrafit nonlinear quadratic model correlating the relationship between the independent and dependent variables were eueragit and shown in where is the dependent variable, is the intercept, to are the regression coefficients, and, and are the independent variables.
The in vitro drug release profiles of the matrices are evaluated, and its release mechanism was studied. Mean dissolution time MDT value is used to characterize drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. The significant effects of the independents variables were graphically demonstrated by 3D surface plots. D response surface plots showing the effect of a ratio of a rzpo to a drug and concentration of a surfactant at constant sonication time and b ratio of a polymer to a drug and sonication time at constant concentration of a surfactant.
Hausner’s ratio was related to interparticle friction and could be used to predict powder flow properties.
Time-controlled Drug release
Unlike other antidiabetic drugs metformin HCl does not induce hypoglycemia at any reasonable dose, and hence it is called as an antihyperglycaemic rather than a hypoglycemic drug [ 2 ]. Therefore, to maintain the oral delivery route, formulating the drug into polymeric nanoparticles is essential for improving the bioavailability.
The direction of the magnitude of significance as shown in 5 was negative for ratio of a polymer to a drug indicating an inverse relationship between ratio of a polymer to a drug and EE.
The percentage errors between measured and predicted values were found to be insignificant. The fitness of the model was checked by coefficient of determination and signal to noise -test. Normally the ratio greater than 4 is desirable for the model to be used effectively [ 28 ].
View at Google Scholar M. Where R and UR are the released and unreleased percentages, respectively, at time t ; k 1k 2k 3k 4and k 5 are the rate constants of zero-order, first-order, Higuchi matrix, Peppas-Korsmeyer, and Hixon-Crowell model, respectively. Click here to view all the property values for this datasheet as they were originally entered into MatWeb.
This may also be the auxiliary reason for obtaining slow drug release profiles through GC and GD matrix tablets.
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Poly ethyl acrylate-co-methyl methacrylate-co-trimethylammonioethyl methacrylate chloride 1: Hausner’s values of srpo prepared granules ranged from 1.
ANOVA was performed to test the significance and adequacy of the model. It is insoluble at rspi physiological pH but the cationic charge facilitates rapid permeation through the intestinal mucosa [ 10 ].
Journal of Nanomaterials
The optimized formulation was characterized for in vitro drug release and structural characterization. Results of the present study demonstrated that combination of both synthetic hydrophilic Eudragit RSPO with natural hydrophobic polymers GC and CD could be successfully employed for formulating sustainedrelease matrix tablets.
From equation, it was observed that ratio of a polymer and concentration of a surfactant had positive effect on mean rxpo size whereas sonication time had negative effect. It was explained that an increase in polymer concentration leads to an increase in viscous force resisting droplet breakdown by sonication [ 35 ].
It has also been used eudrgit the preparations of time-controlled drug delivery formulations [ 12 ].
The reduced model for PDI is presented in where and are ratio of a polymer to a drug and concentration of a surfactant, respectively.
The negative sign for the coefficients in the equation indicates a negative effect on responses, while the positive sign indicates a positive effect [ 8 ]. Nagpur University NagpurIndia. Side effects, short half lives, low bioavailability and the need for the administration two to three times a day when larger doses are required can decrease patient compliance.
Infrared spectrum was taken by scanning the samples of pure drug and the polymers individually over a wave number range of to cm —1 using Fourier transform infrared spectrophotometer FT-IR, Shimadzu S, Shimadzu, Japan.
Eudragit RSPO | Gum Copal | Gum Damar | Matrix Tablets | Release Kinetics
It was observed that ratio of a polymer to a drug has significant effect rs;o other factors do not have an effect on EE. This could be attributed to an ionic electrostatic interaction between the drug and the polymer during formation of nanoparticles. Eudragit RS PO is a derivative with quaternary ammonium functional group [ 10 ].
All other tested factors eudragti their interaction did not eudragiy an effect on PDI. It was also found that SDS was able to increase the drug solubility by threefold when compared to the solubility of tenofovir in water.
We advise that you only use the original value or one of its raw conversions in your calculations to minimize rounding error.
Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. This can be due to the fact that an increase in polymer concentration led to an enhancement of the concentration gradient between emulsion droplets and the continuous phase, as a result increasing the amount of drug partitioning into espo continuous phase [ 38 ]. The change in spectra of the drug in the presence of polymer was investigated which indicates the physical interaction of drug molecule with the polymer.