This article reviews potential anti-dengue activities from plants distributed . In the Philippines, Euphorbia hirta, known locally as “tawa–tawa”. Management of thrombocytopenia and flu-like symptoms in dengue patients with herbal water of Euphorbia hirta. Mir M, Khurshid R, Aftab R. BACKGROUND. PDF | Euphorbia hirta commonly known as Tawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue.

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Inhibitory potential of neem Azidarachta indica Juss leaves on Dengue virus type-2 replication.

It is a flowering vine native to Southeast Asia and cultivated in Indonesia and Thailand mostly for its fruit. The locals in hirra area speak mostly Ilocano and Pangasinense. The use of medicinal plants also increased with increasing age to imply that the high dependence of these three indigenous communities on plants to treat illnesses is still higta with time. The disease not only is onerous to healthcare but also adversely impacts the economy caused by illness, premature death, and increased healthcare costs [ 4 ].

Azidarachta indica Azidarachta indica belongs to the family Meliaceae. In a cohort study, Paredes et al.

Potential anti-dengue medicinal plants: a review

Natural products as sources of new drugs over the period — However, a carboxy-reduced fucoidan in which glucuronic acid was converted to glucose attenuated the inhibitory activity on DENV2 infection. The inhibitory actions of Hirtw cordata aqueous extract on Dengue virus and Dengue-infected cells. Chowdhury MS, Koike M. However, the number of studies conducted to validate its antidengue activity was found to be inadequate.

Essential oils from Lippia alba and Lippia citriodora showed a considerable inhibitory effect on dengue virus serotype replication in Vero cells [ 23 ].


Furthermore, reduction of bleeding time in treated rats, compared to that of control rats, indicates an increase of platelet counts [ 21 ]. An ethnobotanical study of medicinal plants and traditional therapies on Batan Island, the Philippines.

Similarly, the decrease in hematocrit values was not significant. Figure 1 presents the search strategy used in selecting the articles. Dengue, ethnopharmacological, Euphorbia hirtaPangasinan. Climate change impacts and responses in the Philippines: It is robust perennial climber that grows in many of the tropical and subtropical regions of the Old World, India, Southeast Asia, Polynesia and Australia.

View at Google Scholar S. Eight full papers were entitled to the review; out of those, two studies focused on ethnobotanical surveys, three on animal experiments, one on human trial, and two on in vitro antiviral activities, and one was computational study. Most dengue infections are characterized by non-specific symptoms including frontal headache, retro-orbital pain, body aches, nausea and vomiting, joint pains, weakness and rash [ 1213 ].

Annu Rev Microbiol Table 1 shows the number of informants interviewed and the frequency of use reports relative to any symptom in the jirta sampling sites surveyed. In the endosome, hirtx virus penetrates deep into the cell until the endosome membrane acquires a negative charge, which allows it to fuse with the endosomal membrane to open a port for release of genetic material.

The use of herbs, however, is not a new phenomenon. Hence, this study indicates that the E. Lippia alba and Lippia citriodora belong to family Verbenaceae. It is transmitted to humans by Aedes mosquitoes, mainly Aedes aegyptian urban breeding mosquito [ 1 ].

Potential anti-dengue medicinal plants: a review

Management involves supportive care. A validated semi-structured questionnaire was used to determine the number of use report for each specimen collected. The number of cases rose in following decade of dsngue with 26, cases; however, the fatality rate was down to 0.


Journal of Natural Medicines. J Vector Ecol 29 2: The available research highlights the information available for various parts and extract types of medicinal plants for the treatment of dengue.

Despite these developments, there is no concrete evidence that reveals the effectiveness of this plant in humans infected with the dengue virus. Others strategies include the use of plants with bioactive substances that have toxic properties to the vector or dengje properties [ 20 ].

Further, this study established an alteration of clotting time by E.

Bock G, Goode J eds New treatment strategies for dengue and other flaviviral diseases. The leaves of E. The flavonoids isolated from T. The contour lines of the January and July isotherms indicate the potential geographical limits of the northern and southern hemispheres for year-round survival of Aedes aegyptithe principal mosquito eu;horbia of dengue viruses.

An algal-derived dl -galactan hybrid is an efficient preventing agaent for in vitro Dengue virus infection.

Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence

If pursued from drugs derived from uirta plants around the continents, this work may prove valuable to the health of individuals and to nations. A possible strategy in the treatment of dengue is to use chimeric tetravalent vaccines that show high neutralizing antibody against all dengue serotypes [ 915 ]. Jayawardenaand Chanika D.