Diagnostic de l’intoxication digitalique et son traitement. Ferrero C. Author affiliations. Clinique universitaire de Médecine Interne, Hôpital Cantonal, Genève . Request PDF on ResearchGate | Intoxication digitalique en période néonatale: rôle de la déshydratation | Background Despite the great progress which has. Request PDF on ResearchGate | Intoxication digitalique massive. Traitement par hémoperfusion sur résine Amberlite XAD 4 | Haemoperfusion over amberlite.

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It is recalled that the signs of glycosides digitalis impregnations may manifest at therapeutical doses. Digoxin immune Fab therapy in the management of digitalis intoxication: The efficacy and safety of the early immunological treatment by Fab antibodies has modified the therapeutical approach and prognostic [7].

Neurosensorial disorders Approximately one quarter of the patients suffer in early stages from clouding of consciousness, somnolence or restlessness with anguish. Journal page Archives Contents list.

The last two are responsible for this intoxication. In the presence of at least three pejorative factors: The treatment consists of electrolytic controls, supplements when needed and anti-arrhythmic agents if there digitaliqhe a significant presence of dysrhythmias. Contact Help Who are we? Access to the PDF text. Table 1 Pharmacokinetic characteristics.

Intoxication Digitalique

Clinical manifestations Digestive disorders, neurosensorial disorders and cardiovascular disorders are classically associated in clinical table of the digitalis intoxication. Kinetics of the Fab fragments of digoxin antibodies and of bound digoxin in patients with severe digoxin intoxication.

Risk factors and manifestations of digoxin toxicity in the elderly. Recognition and management of digitalis toxicity. Which decreases the sodic transmembrane gradient responsible for moving out calcium by the antiporter, while calcium continues to enter to the cell in each depolarization.


Top of the page – Article Outline. The high cost often limits the access to the hospital centers [7]. The solution should be previously filtered with a 0. The recommended therapeutical concentrations are of 0.

Access to the full text of this article requires a subscription. Automatism disturbances To the ventricular floor it may consist of a ventricular extra systoles, more or less frequent, and tachycardia or ventricular fibrillation. The ourcome was favorable four hours after administration of the first dose of anti-digoxin antibodies, with a complete reversal of clinical and electrocardiographic signs.

It is part of the arsenal therapeutic of atrial fibrillation, supraventricular tachycardia and congestive heart failure. They are frequent and at very early stage without. Atropine administration must be taken into account in case of sinus bradycardia or atrioventricular block AV of the second and third degree to correct the effects of vagal stimulation. Assessment of the synergistic relationship between serum calcium and digitalis.

J Am Coll Cardiol Effect of the sympathetic tone regulation There is a direct effect of digitalis glycosides on the carotid baroreflex response to pressure variations diminished sensitivity in heart failure, might be restored by inhibition of the baroreceptors ATPaseinducing a decrease in the sympathetic tone.

Médecine thérapeutique

This article has been cited by other articles in PMC. Once the diagnosis of intoxication digitalis is intoxlcation, the treatment to use will depend on the degree of risk associated to the patient: These electrical changes happen to the T wave and the ST segment with a flattening digitaliqud the T wave, which becomes negative but remains asymmetric, lowering of the J-point and a sub-offset of the ST segment characterized by a cupule to the upper concavity called “cupule digitalis” Figure 3.


Treatment of cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. The digitalis glycosides constitute a homogeneous group of cardiotonics glycosides with different pharmacokinetic properties, digoxin is the digitalis currently used.

Digitalis intoxication shows intoxicatino in electrocardiogram ECG abnormalities that can lead to arrhythmia potentially fatal and in different signs and symptoms that are not specific. Phenytoin diphenylhydantoin treatment of massive digoxin overdose. Equimolar Neutralization Semi-molar neutralization In the presence of a single pejorative factor: Despite being very familiar with digitalis, its use always asks for particular attention.

Abstract Despite being very familiar with digitalis, its use always digitaliqur for particular attention.

Role of hypoxia in digitalis toxicity. Electrophysiological action At therapeutic concentrations, the digitalis glycosides decrease automaticity and slow atrioventricular conduction. Effects of verapamil on electrophysiological properties of anomalous atrioventricular connexion in Wolff-Parkinson-White syndrome. N Engl J Med.

Allergic histories and reactions of patients treated with digoxin immune Fab ovine antibody. Other digestive disorders, abdominal pain such as cramps and diarrhea sigitalique sometimes observed reflecting vagal hyperactivity. Disorders of impulse conduction and impulse formation caused by hyperkalemia in man. The digibind study advisory panel. The subcellular basis for the mechanism of inotropic action of cardiac glycosides. This decrease in the free fraction in plasma promotes the dissociation of digoxin at the level of its binding sites.